抄録
The antiviral effect of Guanidine on poliomyelitis virus in HeLa cells was investigated. 10-3M of Guanidine exerted the remarkable inhibitory effect on the multiplication of all of type-1, type-2 and type-3 of poliomyelitis virus. The inhibitory effect of Guanidine should neither be due to the virus inactivating action nor be caused by the influence on the viral adsorption onto host cells. From the results presented in this paper, it should be emphasized that the action site of this compound should be in the intracellular viral multiplication, particularly in the reproduction stage of the multiple cycle of viral growth.
