The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
POTENTIATION OF AMINO ACID ANTAGONISTS ON ANTIVIRAL EFFECT OF GUANIDINE
TAKEO UEDASHIGESHI TOYOSHIMAATSUSHI TAKADAYOSHIKO SETO
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1963 Volume 12 Issue 3 Pages 131-137

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Abstract
(1) In order to find more effective agents than guanidine, potentiating agents were searched by means of the salt formation.
(2) The potentiating effect of some amino aicd antagonists was examined, and ethionine was found as the most marked potentiation agent among the antagonists.
(3) The potentiating effect of some of methionine homologs was examined, and any of the homologs was found not to have an effect more significant than ethionine.
(4) The potentiating effect of some of commoner organic acids was examined, but any of these acids was found not to show any potentiating effect.
(5) The mechanismus of the potentiation of guanidine with ethionine was speculated, from the hypotheses presented so far.
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