FRACTIONATION OF PLASMINOGEN ACTIVATOR AND PROACTIVATOR IN TISSUE AND BLOOD BY GEL FILTRATION

Abstract

1) Fractionation of fibrinolytically active components of blood and tissue was carried out.
2) There are two kinds of proactivators in the normal human plasma, proactivator A and proactivator B.
3) Fibrinolytic components of blood may probably be dissociated to a smaller particle in urea solution, and the smaller one is yet fibrinolytically active.
4) The amount of proactivator A in purified plasminogen is very small, which may be removed during the purification procedures.
The authors wish to express their hearty thanks to Prof, S. Okamoto, Kobe University, for his advice and kind discussions.