EFFECTS OF IMMUNIZATION PROCEDURES IN EXPERIMENTAL TOXOPLASMOSIS

Abstract

1. Toxoplasma vaccines were prepared from whole and sonically-disrupted organisms, and administered to mice with or without Freund's adjuvants. None of these vaccines proved effective against a subsequent challenge with the lethal RH strain of Toxoplasma gondii.
2. Passive immunization of mice with rabbit and pig antisera likewise failed to protect mice against a RH challenge.
3. The passive transfer of peritoneal exudate cells from immune to nonimmune mice was ineffective, although diffusion chamber studies indicated that immune macrophages were able to inhibit the growth and multiplication of RH trophozoites.