The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
ANTIVIRIN, A NEW VIRAL INHIBITORY FACTOR PRODUCED FROM CELLS CULTURED IN THE ABSENCE OF VIRAL INFECTION
YOSHIKO SETOSHIGESHI TOYOSHIMA
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1967 Volume 16 Issue 1 Pages 37-48

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Abstract
A new antiviral inhibitor was produced from cell-culture in the absence of Interferon inducing factors. This substance was referred to as ANTIVIRIN. This inhibitor was produced from the culture of many stable-cell-lines and primary cultured cells. The effect of this inhibitor was of rather wide spectrum. Both of RNA viruses and DNA ones were inhibited with this inhibitor. According to the experimental results, it was suggested that this inhibitor must be a complicated protein, but it is not sure at the present time whether sugar or nucleic acid participate in the active component or not.
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