THE EFFECT OF CORTISONE ACETATE ON THE ORAL INOCULATION WITH CANDIDA ALBICANS IN THE GERM-FREE MICE

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There was no macroscopic or microscopic ulcer found in the stomach of ICR germ-free mice even when they were treated with relatively large doses of cortisone. When the germ-free mice were orally inoculated with C. albicans combined with subcutaneous administration of cortisone acetate with the doses of more than 5mg, shallow ulcer developed at the site of the junction between forestomach and glandularstomach in the majority of the cases. In the base of ulcer, candida showed not only hyphal form but also other various forms. Polymorphonuclear leukocytic infiltration with candida organisms was observed at the site of the junction of the forestomach and glandularstomach shortly after oral inoculation with C. albicans. It was considered that the development of ulcer was secondary to the affection of candida. These results indicate that the lowering of the host resistance play an important role on the developement of systemic candida infection.