METABOLISM OF FATTY ACIDS IN CHOLESTEROLESTER

Abstract

Cholesterol-C¹⁴-oleate and cholesterol-C¹⁴-linoleate were administered in albino rats either orally through a catheter or by injection, to measure the specific activity of each fat in the serum, liver and depot fat in a chronological sequence.
As a result, scarcely any radioactivity was demonstrated in triglyceride, diglyceride, monoglyceride, free cholesterol, free fatty acid, phospholipid fraction and depot fat (triglyceride) when injection was employed, unlike oral adminis-tration through a catheter. The fatty acid of the orally ingested cholesterolester is hydrolyzed within the digestive tract, absorbed and transferred to other fats. However, the fatty acid of cholesterolester injected into the body or synthesized in the body is probably not transferred to other lipids.