The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
CHEMOTHERAPEUTIC EFFECT OF N1-DODECANOYL-N4-ACETYL-4-AMINONAPHTHALENE-SULFONAMIDE-(1) ON NEUROTROPIC VIRUSES
CHEMOTHERAPEUTIC DRUGS AGAINST VIRUSES XVI
TAKEO UEDASHIGESHI TOYOSHIMATSUNEO WACHI
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1953 Volume 2 Issue 4 Pages 159-165

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Abstract
(1) PANS-No. 610 shows a remarkable effect on the Japanese encephalitis virus in vitro and in vivo. It is effective even at a longer interval after the inoculation of the virus.
(2) The drug shows a weak effect in vitro and in vivo on the Lansing virus.
(3) The drug possesses a comparatively low toxicity.
(4) It is assumed that the effect of the drug on the Japanese encephalitis virus might be caused by its neurotropy, cerebrotropy and penetration-power into cells in host, related to its surfactant properties.
(5) The drug is of promise for the treatment of the diseases caused by the Japanese encephalitis virus.
(6) It may be claimed that the drug is the only compound which has been confirmed to have chemotherapeutic effects on patients suffering from the so-called small virus such as the Japanese encephalitis virus.
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