Abstract
The infectivity in oral infection of mice with S. enteritidis was markedly enhanced by oral pre-administration of streptomycin. The effect of streptomycin was noted when the drug was administered from 6 to 48 hours before inoculation.
The enhanced infectivity was usually accompanied by the decrease in number of some normal intestinal flora at the time of inoculation and the subsequent multiplication of the inoculated organism in the intestines.
Among the normal flora that were decreased in number, lactobacilli seemed to have the most striking reciprocal relation to the inoculated organism. Coli-proteus group bacilli also decreased in number frequently after streptomycin administration.
