The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions
Joo-In ParkSophia Y. TsaiMing-Jer Tsai
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2003 Volume 52 Issue 3 Pages 174-181

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Abstract

Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are one of the most characterized orphan receptors of the steroid/thyroid hormone receptor superfamily. COUP-TFs play important roles in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryonic development. COUP-TFs were generally considered to be repressors of transcription, however, there are growing evidences that COUP-TFs can function as transcription activators. Here we will review the molecular mechanism of COUP-TFs as repressors and activators. Also, we will review the known biological function of COUP-TFI during development and differentiation.

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