ANTI-ANAPHYLACTIC ACTION OF CHLORPROMAZINE

Abstract

The effect of Chlorpromazine which is a blocking agent of autonomous nerves upon anaphylactic shock were experimentally studied and the following inhibitory actions of this drug were found.
1. The administration of more than 1.0mg/kg of Chlorpromazine was able to protect guinea pigs from the death caused by passive anaphylactic shock.
2. Chlorpromazine inhibited both prophylactically and symptomatically the passive and active local anaphylaxis of the intestine of guinea pigs and rabbits as observed with Magnus technique.
3. Chlorpromazine prevented the Arthus reaction in rabbit skin.
4. From the above results, the anti-anaphylactic actions of Chlorpromazine are considered to be effected both centrally and locally.