THE INFLUENCE OF DIETHYLSTILBESTROL DIPHOSPHATE ON THE CLOTTING MECHANISM IN HUMAN BEINGS
1959 年 8 巻 2 号 p. 109-116
詳細
1959 年 8 巻 2 号 p. 109-116
The effects of intravenous administration of Stilphostrol on the clinical status and on certain factors in blood coagulation were studied in 25 aging subjects.
Of the subjects with initially normal clotting times, in 80% there was no significant change after Stilphostrol administration, while there was a definite decrease in 80% of those subjects whose initial clotting times were over 8 minutes.
A definite decrease in bleeding time occurred in less than one-third of the subjects with control values over 4 minutes, and in none of those with initially normal levels.
Clot retraction time and prothrombin time were apparently unchanged.
Frequently noted side effects were restlessness and sensations of itching and burning localized in the sacral region and perineum.
Stilphostrol appears to play a role in normalizing some factors concerned with the coagulation of blood, chiefly clotting time, and to a lesser extent, bleeding time, when these are abnormal, but the mechanism of its action is unknown.
I am indebted to prof. T. Mc Gavack in New York Medical College for giving the opportunity to do this study and to prof. I. Mikata in Keio University for his guidance.
