巻号一覧
8 巻, 2 号
選択された号の論文の6件中1～6を表示しています
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TAKEO UEDA, SHIGESHI TOYOSHIMA, TADAKAZU TSUJI1959 年 8 巻 2 号 p. 57-64
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリーAlkylbenzenesulfonamide was screened as to its effect in vitro and in vivo on Lansing strain virus. The relationship between activity and alkyl chain length of the above compounds are discussed.
p-Methylbenzene-phenylsulfonamide was selected as the most effective among the series of alkylbenzenesulfonamide and p-methylbenzene-alkylphenylsulfonamide.
This compound was effective on the Lansing strain in vitro and in vivo tests using mice.
Its maximum effective concentration in in vitro test was 250 γ/ml and the optimum dose in the in vivo test was 12-14mg/kg by the intravenous administration.抄録全体を表示PDF形式でダウンロード (387K) -
KONOSUKE NAKAMURA1959 年 8 巻 2 号 p. 65-70
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリー1. The salt discharge of isolated single myelinated nerve fibres of the sciatic nerve-sartorius muscle prepations of the Japanese toads has been studied.
2. The denuded part of the nerve produced active salt discharge.
3. It was difficult to make the isolated single myelinated nerve fibre produce salt discharge.
4. The nerve reduced to several nerve fibres produced the salt discharge as well as the denuded part of the nerve.
5. The denuded central site of the single nerve fibre exhibited the salt discharge in all examples, and it was confirmed, that most nerve fibres in denuded part of the nerve produced salt discharge.
6. The reason why isolated single muscle fibres or single nerve fibres never produce salt contraction or salt discharge, was discussed. It was concluded that the absolutely intact state of a muscle or nerve fibre is necessary to produce salt contractions of muscle or salt discharge of nerve.抄録全体を表示PDF形式でダウンロード (338K) -
THE EFFECT OF PROSTIGMIN, D. F. P. AND PAROTIS HORMONMICHIO SAKANOUE1959 年 8 巻 2 号 p. 71-79
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリーThe author have seen 10 cases of myasthenia ocularis originally named by Tanobe, to be measured cholinesterase-activity in plasma and red cell by electrometric method and observed the change of cholinesterase-activity by the administration of prostigmin, D. F. P., and parotis hormon compared with the palpebral aperture, and obtained the following results.
(1) The cholinesterase-activity in serum of all cases were excessive than normal average.
(2) After administration of prostigmin serum cholinesterase-activity were markedly below than those of the value before administration and palpebral aperture were enlarged.
(3) After administration of D. F. P. cholinesterase-activity in serum were impeded about 50 to 60 per cent, and cholinesterase in red cells were also slightly impeded, but no clinical improvement was appeared.
(4) The author assumed that the fault in myasthenia ocularis may be due to a decreased formation of acetylcholine at myoneural junction, the existence of some abnormal substance in the blood which has a curarelike action, a destructive action for acetylcholine synthesis, and also due to relative decrease of cholinacetylase to be reciprocal with cholinesterase.
Finally the author expresses his sincere thanks to Prof. M. Uemura, Assistant Prof. K. Katow, and Instructor K. Kawashima for continuous guidance and encouragement.抄録全体を表示PDF形式でダウンロード (472K) -
BUNYA NAKAMURA, MASAHIRO KOJIMA, MITSURU OSANO1959 年 8 巻 2 号 p. 81-97
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリー1) Persistence of the resident strains of intestinal E. coli in artificial feeding infants has proved to be shorter compared to that of adults especially in summer season.
2) There was no similarity in identical twins in regard to intestinal flora of E. coli.
3) Change of room in the same house, slight case of so-called cold, exposure of body in sleep, surgical scarlet fever, chicken pox, infantile eczema, skin infection, mild case of diarrhea of a few day's duration and therapeutic dosis of penicillin, sulfa drugs, streptomycin, INH, successive administration of Lact. bifidus and inoculation of pertussis vaccine have no effect on the resident strains.
4) In cases of amoebic dysentery there were found no steady resident strains during infection. However, in other two cases invaded by pathogenic E. coli O 55 during epidemic there was no effect on resident strains.
5) Resident strains were affected by change in infant-home, outing, change of diet, such as the first feeding of cereal or vegetable, diarrhea of comparatively long duration, vaccination against small pox, BCG vaccination and parenteral infection on some occasions.抄録全体を表示PDF形式でダウンロード (1009K) -
I. FINE STRUCTURE OF ENTAMOEBA HISTOLYTICAMAKOTO OSADA1959 年 8 巻 2 号 p. 99-108
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリーElectron-microscopic observations on Entamoeba histolytica were made. Morphological details on the trophozoites, precesses of encystations and degeneration are investigated.
1) Trophozoite has a definite outer membrane. The nuclear membrane is consisted of two layers having minute perforations.
2) The chromatine granules lining the nuclear membrane are made of a substance of a high electron-density.
3) No structural differences were observed by the electron-microscopic observation between the endo and ectoprasm except the former contains vacuoles and ingested inclusions.
4) The encystation takes the following process : rounding off of the cell, decrease in number and then disappearance of vacuoles, production of glycogen vocuoles, then the chromatoid bodies and finally the cyst-membrane.
5) The degeneration process of the trophozoite is as follows: rounding oft' of the cell, disappearance of vaculoes and inclusions in the cytoplasm, vacuolization of the cytoplasm and nucleoplasm, decrease in number and increase in size of the chromatine granules, rupture of the outer membrane and flowing out of the cytoplasm.
6) Mitochondoria, endoplasmic reticulum (in a narrow sense) and Golgi's apparatus were not found in Entamoeba histolytica.抄録全体を表示PDF形式でダウンロード (10453K) -
HERLEY FUJIY1959 年 8 巻 2 号 p. 109-116
発行日: 1959年
公開日: 2009/03/27
ジャーナル フリーThe effects of intravenous administration of Stilphostrol on the clinical status and on certain factors in blood coagulation were studied in 25 aging subjects.
Of the subjects with initially normal clotting times, in 80% there was no significant change after Stilphostrol administration, while there was a definite decrease in 80% of those subjects whose initial clotting times were over 8 minutes.
A definite decrease in bleeding time occurred in less than one-third of the subjects with control values over 4 minutes, and in none of those with initially normal levels.
Clot retraction time and prothrombin time were apparently unchanged.
Frequently noted side effects were restlessness and sensations of itching and burning localized in the sacral region and perineum.
Stilphostrol appears to play a role in normalizing some factors concerned with the coagulation of blood, chiefly clotting time, and to a lesser extent, bleeding time, when these are abnormal, but the mechanism of its action is unknown.
I am indebted to prof. T. Mc Gavack in New York Medical College for giving the opportunity to do this study and to prof. I. Mikata in Keio University for his guidance.抄録全体を表示PDF形式でダウンロード (469K)
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