Abstract
Alkylbenzenesulfonamide was screened as to its effect in vitro and in vivo on Lansing strain virus. The relationship between activity and alkyl chain length of the above compounds are discussed.
p-Methylbenzene-phenylsulfonamide was selected as the most effective among the series of alkylbenzenesulfonamide and p-methylbenzene-alkylphenylsulfonamide.
This compound was effective on the Lansing strain in vitro and in vivo tests using mice.
Its maximum effective concentration in in vitro test was 250 γ/ml and the optimum dose in the in vivo test was 12-14mg/kg by the intravenous administration.
