Abstract
By means of the viscosimetric method, the inhibitory effect of E-A.C.A. on plasmin caseinolysis was studied.
(1) ε-A. C. A. inhibits competitively S. K.-activation process of human plasminogen.
(2) a) At high concentrations, over 2%, ε-A. C. A. inhibits noncompetitively caseinolytic activity of plasmin produced from human globulin with S. K.
b) At low concentrations, below 1%, it enhances caseinolytic activity of plasmin.
This enhancing effect was not seen when ε-A.C.A. was added to casein before the latter was affected by plasmin. (Fig. 6)
I should like to thank the members of the Technical Center of the Research
Project on Plasmin and Antiplasmin and Prof. S. Okamoto.
