ゲルトネル腸炎菌感染マウスに関する病理組織学的研究
第2編 再感染に対する肝, 脾, 淋已節の反応について
1962 年 12 巻 6 号 p. 378-404
詳細
1962 年 12 巻 6 号 p. 378-404
In this paper, the histopathological study of the liver, the spleen and lymph nodes of both groups reinfected with 10-7mg of virulent strain of S. enteritidis 3 weeks after infection with 10-5mg attenuated strain, or thrice infected with 10-5mg or 10-2mg virulent strain 3 weeks after reinfection again, was discribed to elucidate the mechanism of reimmunization with living bacteria.
The group of reinfected mice was divided into two groups that is to say, A group : survival mice achieved high grade immunity, B group : death in the cause of septicamia with allergic reaction. On the other hand, all mice thrice-infected with 10-5mg virulent strain was survival and obtained highest grade immunity, and mice with 10-2mg, almost died within 6 days in the cause of allergic reaction.
Histopathologically, survival mice of both group exhibited tubercles which were break down owing to Arthus's phenomenon within 24 hours after re- and thriceinfection, and afterwards, showed slight proliferation with PAS reaction positive substances of reticuloendothelial cells on each investigated tissues, and multification of plasma cell with large amount of Rassel's bodies in the lymphatic medullary cord.
Sacrificed mice of each group showed remarkable infiltration of inflammatory cells and reticuloendotheliosis on each reseached tissues, multiple necrosis of liver cells and reticuloendothelial tissue in the spleen, bacterial colonies, fibrinous thrombus and histiocytosis in blood vessel cavity, and so forth.
It is considered that those complicated morbid changes of each survival group were related to reaction of mechanism reimmunized with living bacteria, and that most resemble to those of human salmonellosis.
