第2篇 基礎的研究

抄録

Functional relation beteen gonad and thyroid was investigated clinically and experimentally, and the following points were elucidated :
(1) BMR, PBI and I¹³¹uptake were simultaneously assayed mainly on amenorrheal patients out of 200 cases with menstrual disorders, and thyroid dysfunction was observed in about 10% of them. In the majority, the above mentioned values were low, but unlike the hitherto published reports, they were neither predominantly low nor predominantly high.
(2) In single test, abnormal value was given by 30% in average.
(3) Abnormal values were given more in the 2nd grade amenorrhea than in the other menstrual disorders.
(4) With prolongation of amenorrhea, the assayed values tended to fall. In some of them, therefore, hypothyroidsm seemed to be the result of amenorrhea rather than its cause.
(5) Investigation revealed correlation of menstrual disorders to PBI and I¹³¹uptake.
(6) As for the relation between various urinary hormone values and thyroidal function, PBI corresponded with estrogen, and BMR and PBI tended to lower with decline in gonadotrophin value.
(7) Menstrual disorder was seen approximately in 90% of thyropathic patients. But it was, in many, transient, and there was scarcely any relation between grades of thyroidal and ovarian function. In hyperthyroidism, urinary estrogen, gonadotrophin and 17KS were high.
(8) Some cases of menstrual disorder resulted from metabolic insufficiency
(9) Thyroid therapy was efficient on patients with menstrual disorder in whom thyroid function assay found abnormality, But it was harmful when used only empirically.
(10) In immature rats with hypothyroidism, action of PMS was remarkably increased. This was not observed after hypophysectomy
(11) The same was not observed in the action of HCG.
(12) When thyroidal function was enhanced in immature rats, PMS action mostly diminished, This was not the case with hypophysectomized rats.
(13) Action of estrogen on the uterus was altered by the administration of thyroxine.