Isoprophenamine の動物行動に及ぼす影響
誘発行動における抗アンフェタミン作用について
1968 年 18 巻 5 号 p. 501-505
詳細
1968 年 18 巻 5 号 p. 501-505
The “cloister method” was used for evaluating the acute and chronic effects of Isoprophenamine onmice behavior.
Results may be summarizeb as follows.
1. In acute administration tests, the effectof Isoprophenamine (10 mg/kg) on mice behavior was similar to that of saline controls.
After administration of a relatively high dose of Iscprophenamine (20 mg/kg), reduction of motor activity was observed.
2. In chronic administration tests, 10 mg/kg of Isoprophenamine was given daily in the diet over a 4-week period. No obvious behavioral changes were observed in those animals compared with control animals who received no Isoprophenamine.
3. In the above-stated chronic administration tests, Methamphetamine-induced hypermotility and a high rate of R% (a ratio of cyclic walk) which was describedin detail in a previous paper was markedly dimiuished.
