Abstract
This report is concerned with adjuvant chemotherapy of gastric cancer. Since 1962, we had_ tried gastric arterial infusion of anti-cancer agents during radical operation of stomach cancer.
Recently, Hepatic arterial infusion has been combined simultaneously with gastric arterial infusion. The side effects of Mitomycin C (MMC) and 5-Fluorouracil (5-FU) on the iron metabolism in the bone marrow in regard to ferrokinetics and hematopoietic impairment produced by that infusion treatment were studied after Huff's method.
1) In blood picture and liver function, there were little disorder.
2) Plasma iron disappearance time 1/2 (PIDT 1/2) markedly increased postoperatively after 4 days, but after 14 days, it was about the same as the preoperative.
On the other hand, during the past three years in our surgery, 5-FU was administered intravenously of 55 patients with carcinoma or sarcoma of the stomach.
3) The toxicity of the drugs was found in patients subjectively and in 3 cases objectively, and the common toxic reactions were as follows : 9 diarrhea, 6 loose stool, 5 nausea and vomiting, 4 general fatigue, 4 anorexia, 1 stomatitis; 2 liver disorder, 1 leucopenia.
4) For the purpose of prevention of these toxic reactions, Inosine, Vitamin B6 and B12, and Glutathione were given to patients after surgery, with a little favorable effect.
