This report is concerned with adjuvant chemotherapy of gastric cancer. Since 1962, we had_ tried gastric arterial infusion of anti-cancer agents during radical operation of stomach cancer.
Recently, Hepatic arterial infusion has been combined simultaneously with gastric arterial infusion. The side effects of Mitomycin C (MMC) and 5-Fluorouracil (5-FU) on the iron metabolism in the bone marrow in regard to ferrokinetics and hematopoietic impairment produced by that infusion treatment were studied after Huff's method.
1) In blood picture and liver function, there were little disorder.
2) Plasma iron disappearance time 1/2 (PIDT 1/2) markedly increased postoperatively after 4 days, but after 14 days, it was about the same as the preoperative.
On the other hand, during the past three years in our surgery, 5-FU was administered intravenously of 55 patients with carcinoma or sarcoma of the stomach.
3) The toxicity of the drugs was found in patients subjectively and in 3 cases objectively, and the common toxic reactions were as follows : 9 diarrhea, 6 loose stool, 5 nausea and vomiting, 4 general fatigue, 4 anorexia, 1 stomatitis; 2 liver disorder, 1 leucopenia.
4) For the purpose of prevention of these toxic reactions, Inosine, Vitamin B6 and B12, and Glutathione were given to patients after surgery, with a little favorable effect.

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In an attempt to clarify the mechanism of the local Shwartzman reaction, immunological investigation using immune adherence phenomenon was carried out. And the following results were obtained.
1) Normal rabbits were found naturally sensitized to the endotoxin.
2) After the preparatory injection, the serum complement was decreased and the antibody forming cells in the spleen appeared.
3) After the provocative injection, in vitro clumping as well as rosette formation of the leucocytes by adding complement and endotoxin were intensified.
On the basis of these findings, the role of immune complex and immune adherence phenomenon in the etiology of the local Shwartzman reaction was discussed.

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In order to study the ability of olfactory discrimination, thirsty rats were trained to distinguish a water containing clove oil odor from a water containing anise oil odor and a drop of a rat repellent, naramycin (Tanabe Phamaceutical Comp.) for several days. Then, their ability of discrimination was tested for ten or more days. Experiments were performed on normal rats and on the rats with the anterior limbs of the anterior commissure sectioned, the lateral olfactory tracts sectioned or the olfactory bulbs removed uni- or bilaterally. Thus, the roles played in the olfactory discrimination by these olfactory elements were examined.
1. It was found that fresh untreated normal rats could discriminate these odors completely after training for about six days. When these rats were trained to discriminate between several pairs or odors, their conditioned reactions gradually grew faster.
2. When the olfactory bulbs were removed unilaterally in the fully conditioned rats, discriminative ability decreased once but then began to recover day by day, and recovered nearly completely in about twenty three days. However, it was made clear that the level of the discriminative ability by bilateral olfactory nervous systems can not be attained by a unilateral nervous system. Hemispheric predominance in the discriminative ability was not found between the bilateral olfactory bulbs.
3. Sectioning of the lateral olfactory tracts lowered the ability of the odor discrimination more markedly than sectioning of the anterior limbs of the anterior commissure. This is coincident with Allison's hypothesis that the lateral olfactory tract has finer ability of odor discrimination than the anterior commissure.
4. Rats with both the anterior limbs of the anterior commissure and the lateral olfactory tracts sectioned bilaterally showed better results in the learning ability of discrimination and in the recovery of the discriminative ability after the operation than the rats with the olfactory bulbs removed bilaterally. This suggests the presence of a third olfactory nervous pathway in addition to the above two ones.
5. It was clearly proved that the trigeminal nerve takes a part in the odor discrimination, but that role is not necessarily large.

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An antitumor agent against Yoshida Sarcoma was produced in rat bone marrow cells which were sensitized in vitro with the medium containing the supernatant fluid of medium of X-irradiated Yoshida sarcoma cells.
From 2, 000R to 4, 000R were optimal doses to release an antigenic cellular agent from irradiated Yoshida Sarcoma cells. And a small amount of serum component was necsesary in culture medium of the tumor cells to obtain the antigenic agent.
Specific activity of antigenic activity was determined between tumor cells and normal tissue cells using C3H/He mouse mammary carcinoma and C3H/He mouse kidney cells.
Lymph node cells sensitized with the tumor cell-antigenic-agent did not inhibit the cell growth of normal kidney cells while inhibit the cell growth of target mouse mammary carcinoma cells.
Effect of sensitized lymph node cells and X-Ray irradiation against tumor growth of C3H/He mouse mammary carcinoma which were inoculated into thigh muscle determined.
The tumors were reduced remarkably when they were treated with sensitized lymph node cells and X-Ray irradiation.

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The authors devised an apparatus to obtain the score indicating ability for the quick motion, in which the response to the optical stimulus done within a certain time limit (300msec or 480 msec) could be indicated as well as the total number of the stimuli.
The five neon lamps which were lighted to give optical stimulus and the five keys to push as the response to the given stimulus were arranged on a board (a lamp and key were assembled in one set).
By employing the above apparatus the score to decide the ability was obtained, which was indicated with the number of responses done within the time limit (300msec) for ten stimuli.
The results were the following :
1. The score distributed in a wide range, and differed in each subject.
2. The score seemed to represent agility of daily movement observed on the subject.
3. The score of the same subject obtained on different day, varied little.
4. The score of the same subject obtained in different times varied little and the training effects seem to be negligible the one 2025 times repetition on the same day, the other for 10 days.

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