Abstract
In an attempt to clarify the mechanism of the local Shwartzman reaction, immunological investigation using immune adherence phenomenon was carried out. And the following results were obtained.
1) Normal rabbits were found naturally sensitized to the endotoxin.
2) After the preparatory injection, the serum complement was decreased and the antibody forming cells in the spleen appeared.
3) After the provocative injection, in vitro clumping as well as rosette formation of the leucocytes by adding complement and endotoxin were intensified.
On the basis of these findings, the role of immune complex and immune adherence phenomenon in the etiology of the local Shwartzman reaction was discussed.
