昇汞の体内分布と排泄に関する実験的研究

抄録

²⁰³HgCl₂ was given to mice, and its retention, excretion and distribution were investigated, Furthermore various drugs were examined for ²⁰³ Hg-expelling effect.
1. Retention : The retention after the s.c., i.p. and p.o. administration were daily explored for 3 days. The retention after s.c. administration was highest, and next in order were i.p. and p.o. administration.
2. Distribution : The distribution of ²⁰³ HgCl₂ was determined times daily for 3 days after i.p. administration. The radioactivity was highest in the kidney already at 1 hour, and attained the peak at 4 hours.
The subcellular distribution of ²⁰³ HgCl₂ in the liver and kidney at 24 hours after i.p. administration was greater in the supernatant fraction from both organs than in the other fractions.
3. Effects of administration of various drugs : 3-day experiments on the whole body : The retention of ²⁰³ HgCl₂ after its i.p. administration was decreased by BAL and D-Penicillamine. ²⁰³ Hg Activity was lowered in the kidney, liver, pancreas, spleen, brain and blood by BAL, in the kidney, pancreas and spleen by D-Penicillamine, in the brain by L-CySH·Gly, in the brain and blood by L-CySH, in the kidney by 2-Mercatopropiony glycine and also by Pyridonine-4SH, in the spleen, brain and blood by Mercaptoacetic acid (though it increased ²⁰³ Hg concentration in the kidney), and in the kidney be EDTA and DTPA (though increased in the pancreas and brain).
4. Effect of starvation : The fecal excretion of ²⁰³ HgCl₂was decrease and its retention was increased by the starvation. The absorption of ²⁰³ HgCl₂ was increased by the starvation.