癌性疼痛に対するBrompton cocktail変法モルヒネ単独内服液投与例の検討
有効性, 投与量, 投与期間について
1988 年 38 巻 6 号 p. 499-504
詳細
1988 年 38 巻 6 号 p. 499-504
The use of morphine solution (modified Brompton cocktail, M sol.) given orally to cancer patients in Tatebayashi Kosei Hospital, 1983-87 inclusive was studied. A total of 15 patients (67.1 ± 3.0 years) included 2 with gastric cancer (Ca), 3 with lung Ca, and 1 each with mammary Ca, myeloma, pancreatic Ca, renal Ca, liver Ca, aplastic Ca, osteosarcoma, prostatic Ca, cerebral Ca and lymphoma were treated with M sol. Use of M sol. tended to increase according to the year, but 151 patients were also treated with Brompton cocktail (B.P). M sol. (5 or 10 ml containing 7-20 mg of morphine) was administered to 1 patients once a day, 2 patients twice a day, 4 patients 3 times a day, 6 patients 4 times a day and 2 patients 6 times a day (i.e., daily doses ranged from 7 to 62.5 mg) for 3 to 58 days. Clinical effects in the 15 patients were good in 11, unknown in 1 and poor in 3. The efficacy rate was 73.3% (11/15). The adverse reactions observed were nausea and vomiting in 2 cases, constipation in 2, drowsiness in 2 and a strange taste in I. These did not improve with drug treatment. It is suggested that M sol. is similar to B. P in efficacy for the relief of severe cancer pain and in the high frequency of gastrointestinal symptoms after its administration.
