Seventeen patients with liver cancer were treated with the method of infusion of Lipiodol-Cisplatin (LPD-CDDP) suspension. Serum concentration of CDDP were analyzed with atomic absorption spectrometry in 16 patients. Tissue concentrations of CDDP were measured in two patients.
Plasma levels of CDDP decreased in a biexponential manner, the half-life of the first phase was as long as in intravenous one-shot injection therapy, and also LPD-CDDP sandwich therapy. On the other hand the half-life of the late phase was longer than those. Tumor tissue level of CDDP was the same an normal liver tissues in one patient, but in the other patient the tumor tissue level of CDDP was higher than in normal tissue. These depositions of LPD in CT findings present the tissue concentration of CDDP. It was clinically confirmed that CDDP passes gradually into the systemic circulation after hepatic intra-arterial injection of the LPD-CDDP suspension.
