胃癌患者の各種免疫能に対するレバミゾールの影響
1990 年 40 巻 4 号 p. 375-385
詳細
1990 年 40 巻 4 号 p. 375-385
Eighty-one patients with stomach cancer in 4 different stages were randomly divided into 2 groups and one group of patients was given the immunomodulator levamisole (LMS) preoperatively for 3 days. The effects observed on cellular immunity are as follows.
1) In general, a greater response was observed in stage III and IV patients in the group given LMS and the effect persisted until two weeks after surgery.
2) LMS was found to have positive effects on peripheral blood lymphocyte blastogenesis induced by PHA with or without the addition of autologous sera, similar to those observed in the PHA skin test.
3) With respect to regional lymph node lymphocyte, total T-cell traction and active T-cell traction in the group given LMS increased more than in the group not given LMS. The effect of LMS on lymphocyte blastogenesis induced by PHA and PHA plus autologous sera was more marked in proximal than in distal lymph node.
