Isosorbide Concentration Alters the Bacteria-Repellent Effect of an Isosorbide Polycarbonate

Abstract

The first step for bacteria to cause infection is the attachment to the host. As almost all of the bacteria in the natural world adhere to some solid surface and proliferate, they can become the source for an infection. Therefore, the development of materials that are less prone to bacterial adhesion seems to be useful for the prevention of infectious diseases. Since we found that some isosorbide polycarbonates repell bacteria, we investigated the influence of isosorbide concentration on the repellent effect. The number of attached bacteria, Staphylococcus aureus 209P and Escherichia coli K12, per per surface area decreased significantly (p < 0.01) with increasing isosorbide polycarbonate mole fraction. It seems that the molar fraction of isosorbide polycarbonate changes the surface hydrophilicity and this, greatly influenced the first stage of biofilm formation of S. aureus 209P and E. coli K12.