Abstract
Nucleic acid has attracted attention as a next generation drug. However, since the nucleic acid is a natural molecule, it is degraded by nucleases in vivo. Therefore, to overcome these problems, a drug delivery system (DDS) is indispensable. There is a DNA structure that can precisely control particle size and shape by using DNA nanotechnology. According to recent studies, tetrahedral DNA containing CpG sequences can stimulate the immune system without being degraded by nuclease. This research aims at new DDS carriers with pH responsiveness, using tetrahedral DNA. Tetrahedral DNA induced TNF-α more than CpG-DNA alone, indicating that tetrahedral DNA is an efficient nucleic acid adjuvant.
