Abstract
Glycerol-terminated macromonomers Mac (MPC/BMA) -I-III (Mn=1.9×104, 7×103, 4×103) were obtained from radical copolymerization of 2- (methacryloyloxy) ethyl phosphorylcholine (MPC) and butyl methacrylate (BMA) in the presence of thioglycerol with different concentrations. Polyaddition was conducted for the syntheses of a series of copolyetherurethaneureas [PEU-g-P (MPC/BMA) -I-III] grafted on the copolymer of MPC and BMA with the molar ratio of 0.1: 0.9: 2: 1 for Mac (MPC/BMA) -I-III: polytetrahydrofuran (PTHF): 4, 4′-diphenylmethane diisocyanate (DPMDI): ethylene diamine. Parent polyetherurethaneurea (PEU) and poly (butyl methacrylate) graft copolyetherurethaneurea (PEU-g-PBMA) were also prepared. XPS spectra indicated that the MPC unit is located on the surface of PEU-g-P (MPC/BMA) -I-III. The measurements of equilibrium water content and contact angle to water confirmed that the higher molecular weight of side chains results in higher hydrophilicity of PEU-g-P (MPC/BMA) -I-III surface. The tensile modulus showed values of E=13.3-38.4 MPa for PEU-g-P (MPC/BMA) -I-III films. It was also found that PEU-g-P (MPC/BMA) -I-III suppressed the adsorption of both bovine serum albumin and human serum γ-globulin less than PEU and PEU-g-PBMA. In cell culture test, PEU-g-P (MPC/BMA) -I, III films showed no adhesiveness of mouse fibroblast (L-929). Because of their mechanical and biocompatible properties, PEU-g-P (MPC/BMA) -I-III are expected to be useful as novel biomaterials.
