2021 年 45 巻 2 号 p. 106-111
The skin concentration of topically applied cosmetic active ingredients is very important for evaluating cosmetics. However, the direct measurement of drug concentration in the membrane has several problems. Generally, controlling the removal of the drug formulation from the membrane surface is very difficult. Hard cleaning of the membrane surface decreases the membrane concentration, whereas inadequate cleaning may leave the drug formulation on the membrane. In the present paper, relationship between skin permeation and skin concentration is shown and research results with verification result for utilization to dose setting method guideline for human long-duration trials (Safety) is also introduced. I hope this paper will be helpful to ensure the efficacy and safety of cosmetic products.
