SECONDARY RESTORATION OF THE EXCITABILITY OF FROG'S SKELETAL MUSCLE FIBERS UNDER THE EFFECT OF A METABOLIC INHIBITOR

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The membrane of frog's skeletal muscle fibers is known to be depolarized under the effect of 2, 4-dinitrophenol (DNP) in the bathing Ringer's solution. Since DNP is a powerful inhibitor of oxidative phosporylation of frog's skeletal muscle¹⁾, it is considered useful in investigating whether or not the maintenance of the bioelectrical potential is actually linked to energetic metabolism in excitable cells. The present paper is an account of experiments dealing with secondary restoration of the membrane potential of muscle fibers previously dropped under the effect of DNP. Results of this study may have an important bearing on the problem of the mechanism underlying the maintenance of the bioelectrical potential.