FACTORS AFFECTING PATHOGENICITY OF SERRATIA MARCESCENS FOR MICE

Abstract

Factors affecting pathogenicity of Serratia for mice were studied. Results obtained are summerized as follows. 1. The virulence of Serratia was not affected by passage through mice for ten times, but increased by inoculation of the organisms with gastric mucin. 2. The pathogenicity of Serratia for mice previously treated with antiinflamatory drugs betamethasone, ACTH, indomethacin and lysozyme, was the same as that for nontreated mice. 3. Mice previously treated with azathiopurine as immunosuppressive drugs were less resistant against Serratia infection than non-treated one. 4. Mice suffering from experimental diabetes caused by alloxan, were killed by smaller numbers of Serratia than in the case of non-treated mice.