Adenosine Triphosphate Facilitates the Na+ -K+ Pump of Frog Skeletal Muscle Fibres

KOZUE KAIBARA; MIKIE KOJIMA; KYOZO KOKETSU; TAKASHI AKASU; MICHIKO MIYAOAWA; KEIJI HIRAI; TAKAYUKI TOKIMASA; HIROSHI HASUO; MICHIHISA YAMADA; TOSHIHIKO NISHIMURA

doi:10.2739/kurumemedj.28.113

Adenosine Triphosphate Facilitates the Na⁺ -K⁺ Pump of Frog Skeletal Muscle Fibres

KOZUE KAIBARA, MIKIE KOJIMA, KYOZO KOKETSU, TAKASHI AKASU, MICHIKO MIYAOAWA, KEIJI HIRAI, TAKAYUKI TOKIMASA, HIROSHI HASUO, MICHIHISA YAMADA, TOSHIHIKO NISHIMURA

Author information

KOZUE KAIBARA
Department of Chemistry, Faculty of Science, Kyushu University
MIKIE KOJIMA
Department of Chemistry, Faculty of Science, Kyushu University
KYOZO KOKETSU
Department of Physiology, Kurume University School of Medicine
TAKASHI AKASU
Department of Physiology, Kurume University School of Medicine
MICHIKO MIYAOAWA
Department of Physiology, Kurume University School of Medicine
KEIJI HIRAI
Department of Physiology, Kurume University School of Medicine
TAKAYUKI TOKIMASA
Department of Physiology, Kurume University School of Medicine
HIROSHI HASUO
Department of Physiology, Kurume University School of Medicine
MICHIHISA YAMADA
Department of Physiology, Kurume University School of Medicine
TOSHIHIKO NISHIMURA
Department of Physiology, Kurume University School of Medicine

Keywords: adenosine triphosphate (ATP), Na⁺ -K⁺ pump, frog skeletal muscles, dibutyryl cyclic adenosine monophosphate (dbc AMP), ²²Na⁺-efflux

JOURNAL FREE ACCESS

1981 Volume 28 Issue 2 Pages 113-117

DOI https://doi.org/10.2739/kurumemedj.28.113

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Abstract

Effects of adenosine triphosphate (ATP) and dibutyryl cyclic adenosine monophosphate (dbc AMP) on the Na⁺ -K⁺ pump of cell membrane were studied by testing the effects of these nucleotides on the ²²Na⁺-efflux from frog skeletal muscle fibres. The rate coefficient of ²²Na⁺-efflux was found to be significantly increased by ATP 3 mM. Dbc AMP 3 mM showed no demonstrable effect. These results support the concept that ATP facilitates the electrogenic Na⁺ pump, but do not support the concept that the electrogenic Na⁺ pump is stimulated by cyclic AMP.

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