Effects of Neuroleptics on Dopamine Release from Striatal Slices

SHIGETO YAMADA; HIDEKI KOJIMA; TETSUYUKI TSUTSUMI; HIDEYASU YOKOO; KAZUYOSHI TAKAMUKI; SHIGEMI ANRAKU; SYOGORO NISHI; KAZUTOYO INANAGA

doi:10.2739/kurumemedj.32.127

SHIGETO YAMADA, HIDEKI KOJIMA, TETSUYUKI TSUTSUMI, HIDEYASU YOKOO, KAZUYOSHI TAKAMUKI, SHIGEMI ANRAKU, SYOGORO NISHI, KAZUTOYO INANAGA

Author information

Keywords: superfusion, dopamine release, striatal slices, haloperidol, chlorpromazine, sulpiride

JOURNAL FREE ACCESS

1985 Volume 32 Issue 2 Pages 127-130

DOI https://doi.org/10.2739/kurumemedj.32.127

Details

Abstract

The effects of neuroleptics on dopamine release from rat striatal slices was investigated with a superfusion system. Haloperidol (10^-5M), chlorpromazine (10^-4M) and sulpiride (10^-3M) induced a significant increase in dopamine efflux from rat striatal slices. The onset of the enhancement of dopamine efflux was slower with superf usion of haloperidol than with methamphetamine. This data suggests that the mechanism of enhancement of dopamine efflux by haloperidol may be different from the mechanism of methamphetamine.

Corresponding author

Register with J-STAGE for free!