Experimental Intraperitoneal Administration of Cisplatinactivated Carbon for Rat Ovarian Adenocarcinomas

TORU SUGIYAMA; TAKASHI NISHIDA; SEISUKE KUMAGAI; KIMIO USHIJIMA; ATSUHIKO SHINAGAWA; HIDETO OKINA; YOSHITO TOMIOKA; AKIO KATAOKA; MICHIAKI YAKUSHIJI

doi:10.2739/kurumemedj.43.33

TORU SUGIYAMA, TAKASHI NISHIDA, SEISUKE KUMAGAI, KIMIO USHIJIMA, ATSUHIKO SHINAGAWA, HIDETO OKINA, YOSHITO TOMIOKA, AKIO KATAOKA, MICHIAKI YAKUSHIJI

Author information

TORU SUGIYAMA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
TAKASHI NISHIDA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
SEISUKE KUMAGAI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
KIMIO USHIJIMA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
ATSUHIKO SHINAGAWA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
HIDETO OKINA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
YOSHITO TOMIOKA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
AKIO KATAOKA
Department of Obstetrics and Gynecology, Kurume University School of Medicine
MICHIAKI YAKUSHIJI
Department of Obstetrics and Gynecology, Kurume University School of Medicine

Keywords: drug delivery system (DDS), activated carbon, cisplatin (CDDP), ovarian cancer, experimental intraperitoneal chemotherapy

JOURNAL FREE ACCESS

1996 Volume 43 Issue 1 Pages 33-39

DOI https://doi.org/10.2739/kurumemedj.43.33

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Abstract

Selective delivery of a high level of cisplatin (CDDP) to the omentum, intraperitoneal disseminated tumors and lymph nodes was studied using a dosage form of CDDP-activated carbon. Although intraperitoneal CDDP-activated carbon delivered much higher levels of CDDP to the omentum, tumors and lymph nodes, a primary burst phenomenon of CDDP occurred just after administration. This indicates that activated carbon is an unsuitable particle to provide a slow steady release of CDDP.

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