Abstract
It has been recognized that the apnea caused by intravenously in jected nicotine may be due to the pulmonary respiratory chemoreflex (Takasaki, 1956). The localization of the receptor responsible to the reflex, however, is not yet confirmed.On the other hand, it has been reported that the circulatory reflex originating in the receptor within the heart (Bezold-Jarisch effect defined by Dawes et al., 1954) is blocked by intrapericardial administration of procaine or the other local anesthetics (Kurotubo, 1942., Hukuda, 1951., Kido, 1953).The present experiment attempted to confirm that the receptor in the heart is not concerned in the nicotine apnea, using the intrapericardial in jection of procaine. In addition, the troubles occurred after intrapericardial administration of procaine were examined.
