反回神経麻痺に対する喉頭注入術：注入材料の変遷と効果

抄録

Injection laryngoplasty is an option for the surgical treatment for vocal cord paralysis. Paraffin, Teflon, silicon, autologous fat, collagen, hyaluronic acid, calcium phosphate paste, and basic fibroblast growth factor (bFGF) have been used as injectable materials in clinical settings. Some injectable materials are no longer in clinical use because of potential complications, such as granulation formation, inflammation, and migration. This paper describes the characteristics and therapeutic effects of each injection material. The feature of autologous fat is that it is safe because it is an autologous transplant, and its therapeutic effect is long-lasting to some extent. Collagen and hyaluronic acid are easy to prepare because they are commercially available; however, their therapeutic effect is poorly sustained. Since calcium phosphate paste is barely absorbed in the larynx after injection, its effect can be expected to last for an extended period, and bFGF is a regenerative medicine material, so its absorption does not matter.