抄録
Liquid–liquid phase separation (LLPS) in molecular and cellular biology is approaching its tenth year since the so-called “phase separation boom” that emerged around 2015. In the field of bioinformatics (BI) focusing on LLPS-related proteins, particularly within data science–oriented research, the publication of four LLPS-related databases in the 2020 Nucleic Acids Research Database Issue marked an important milestone. These resources provided a foundational framework for the systematic organization and analysis of proteins involved in LLPS, and this period can be regarded as the point at which data science–driven research in this field began to emerge in earnest. In this review, we provide an overview of studies on LLPS-related proteins from 2020 to the present (2026), with a primary focus on the development and utilization of databases. By highlighting differences in database design concepts and data curation strategies, we discuss the trends and evolution of data science research in this field.
https://ror.org/01x05rm94 
