Field Trial with a Further Attenuated Live Measles Virus Vaccine

抄録

A live measles virus vaccine was prepared with a virus strain attenuated by passage in the primary sheep kidney cell culture. All of 209 initially seronegative children showed seroconversion after subcutaneous inoculation of one dose of the vaccine. The geometric mean of neutralizing antibody titers following vaccination was 2^6.6, Axillary temperature of 37.5 C or higher was recorded in 23.6% of 199 vaccinees with adequate clinical records, but only 4% had fever over 39.0C. The average maximal temperature in feverish children was 38.3C. Fever usually lasted for only one or two days. Neither febrile convulsion nor other toxic reactions was observed.