抄録
Thymidine kinase (TK) was induced in dog kidney cells (DKC) and hamster embryo cells (HEC) infected with infectious canine hepatitis virus (ICHV). The enzyme activity increased and reached levels of 13 and 19 times as much as in uninfected cells by the 30th hr after infection in virus-infected DKC and HEC, respectively. No difference in the pattern of inactivation at 45C was found between the TK of infected and uninfected cells. The activity of the TK from ICHV-infected DKC was not inhibited by a dog serum hyperimmunized against ICHV-infected DKC. From these results it was concluded that the TK which increased in ICHV-infected cells was of the cellular origin.
