STUDIES ON ANTIVIRAL ANTIBIOTICS FROM STREPTOMYCES

IX. THE INHIBITORY EFFECT OF SEVERAL ANTIBIOTICS ON THE GROWTH OF INFLUENZA VIRUS IN EMBRYONATED EGGS AND IN MICE

Abstract

Thirteen antibiotics which inhibited the growth of influenza virus in vitro were examined further to determine their activity in embronated eggs and in mice. Seven antibiotics inhibited the growth of PR₈ virus in embryonated eggs and 3 inhibited viral growth in mice. However, two of the latter demonstrated toxicity for mice at their effective concentrations. Only one of 13 antibiotics, myxoviromycin, inhibited viral multiplication both in embryonated eggs and in mice without any serious toxicity.