抄録
The inhibitory action of trichomycin on the oxidation of D-and L-amino acids is considerably arrested by the presence of excessive amounts of riboflavin. However, the arresting effect of riboflavin on the inhibitory action of trichomycin is observed only in the case when the compound is added simultaneously or beforehand. When the compound was added during the inhibitory activity of trichomycin, no arresting effect is noted. The drug may have a specific affinity for the yellow enzymes and, particularly, inhibits them. These respirometric data suggest that riboflavin may come into antagonism with the inhibitory action of trichomycin on the respiratory metabolism of C. albicans.
In regards to the mode of anti-fungal action of trichomycin, the inhibitory action on respiration is considered as being primary, and that the flavin enzyme system is regarded as the site of trichomycin action. However, the specific action which trichomycin has upon the individual cells of fungi and protozoa will not be definite until more is known about the metabolism and fine structure of living cells.
