抄録
The mitogenic activity of the cell-wall skeleton (CWS) of Nocardia rubraon purified splenic T-cells (thymus-derived lymphocytes) was investigated. N. rubra CWS showed remarkable mitogenic activity on normal spleen cells of C57BL/ 6J mice at concentrations ranging from 10 to 100 μg per milliliter of culture medium, while, on purified splenic T-cells, N. rubra CWS did not act as a mitogen at any concentration. However, mitogenic activity of N. rubra CWS on T-cells was restored if purified splenic T-cells were reconstituted with X-irradiated peritoneal exudate cells (macrophages). The above results suggest the necessity of macrophages for T-lymphocyte activation by N. rubra CWS as well as PHA-P or Con A.
