MICROBIOLOGY and IMMUNOLOGY
Online ISSN : 1348-0421
Print ISSN : 0385-5600
ISSN-L : 0385-5600
Immune Response to Toxoplasma gondii
Alteration of Antigen Specificity of Peripheral Blood Leukocyte Proliferative Responses in Acute Toxoplasmosis
Akihiko YANOFumie AOSAIKeizo YAMASHITAKazuo SUGANEShigeo HAYASHI
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1987 年 31 巻 4 号 p. 345-355

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Ultrasonicated Toxoplasma gondii (RH strain) tachyzoite extract was chromatographed on Sephadex G-200, and one main peak (93, 000M.W.) and three small peaks (>160, 000M.W., 110, 000M.W., and 20, 000M.W.) were eluted. Toxoplasma-specific proliferative T cell responses of peripheral blood leukocytes (PBL) from a patient with acute toxoplasmosis caused by accidental injection of tachyzoites of the protozoa were sequentially examined by using these fractioned antigens. As early as one week after the accidental injection of the protozoa, significant proliferative responses of PBL could be detected. The reaction of proliferative T cells was observed occurring mainly with Fr. II antigen. Then T cells began to respond to Fr. I and III in addition to Fr. II 3 weeks after the injection. Thus, expansion of antigen specificity in Toxoplasma-specific T cell responses was observed at the initial stage of acquired acute toxoplasmosis.
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