Herpes Simplex Virus-Induced Expression of 70kDa Heat Shock Protein (HSP70) Requires Early Protein Synthesis But Not Viral DNA Replication
1994 年 38 巻 4 号 p. 321-325
詳細
1994 年 38 巻 4 号 p. 321-325
The major 70kDa heat shock protein (HSP70), which is scarcely expressed in unstressed rodent cells, was apparently induced by infection with herpes simplex virus (HSV). Infection with HSV types 1 and 2 elevated HSP70 mRNA levels within 4hr post-infection. HSP70 synthesis and accumulation increased in HSV-infected cells. Irradiation of HSV with UV-light abolished the ability to induce HSP70 mRNA. Inhibitors of viral DNA synthesis did not affect the induction of HSP70 in infected cells. Protein synthesis within 2hr after infection was necessary for HSP70 induction.
