抄録
The development of biochemistry and molecular biology has enabled to study the mechanism of various biological systems, such as protein-protein interactions. However, structural biology has been successfully applied to only a few studies of protein-protein interactions. As the development of technologies of X-ray crystallography and nuclear magnetic resonance spectrometry (NMR), it is now possible to obtain precise information on the tertiary structure of proteins. Mass spectrometry is also an effective tool to analyze the structure of large biomolecules. In addition, computational chemistry plays an important role in the study of the protein-ligand interaction. This paper demonstrates how effective mass spectrometry is in the studies of structure-function relationships of biomolecule networks. Prospects of the mass spectrometers for the study of protein structure is also discussed.
