Online ISSN : 1347-5320
Print ISSN : 1345-9678
Effect of β-TCP Size on Bone-Like Layer Growth and Adhesion of Osteoblast-Like Cells in Hydroxyapatite/β-TCP Composites
Hiroyuki Y. YasudaMitsuhiro AokiYohei FujitaWataru FujitaniYukichi UmakoshiAkio Takaoka
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2006 Volume 47 Issue 9 Pages 2368-2372


Hydroxyapatite (HAp)-20 vol% β-tricalcium phosphate (β-TCP) composites were prepared. The effect of β-TCP size on bone-like layer growth and adhesion of osteoblast-like cells on the composites was systematically studied in vitro. When the composites were soaked in a simulated body fluid, the formation and growth rates of the bone-like layer increased with increasing β-TCP size, even if the volume fraction of β-TCP was constant. Moreover, selective dissolution of β-TCP phase and formation of the bone-like layer around the phase were frequently observed. Higher Ca2+ concentration due to the fast dissolution of β-TCP beneath the sample surface resulted in faster formation and growth of the bone-like layer, especially in the samples containing β-TCP powders larger than 100 μm. MC3T3-E1 osteoblast-like cells preferentially adhered to β-TCP phase in HAp/β-TCP composites because of the enrichment of Ca2+ ions around β-TCP.

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© 2006 The Japan Institute of Metals and Materials
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