Preparation of Iron Doped Hydroxyapatite Microsphere by Mist Process

Abstract

Hydroxyapaite and Fe doped hydroxyapatite microsphere were prepared by mist process using Ca(NO₃)₂, FeCl₃ and (NH₄)₂HPO₄ aqueous solutions, and the effects of the preparation condition and Fe doping on the crystal phase, microstructure and other properties were investigated. From XRD analysis, obtained powders were HAp in a single phase at the Ca/P ratio from 1.5 to 2.0, independent from preparation temperature and gas flow rate. In the case of the Ca/P ratio of 1.0, obtained powder was mixed phase of HAp and Ca₂P₂O₇. The crystallinity of powders strongly depended on preparation temperature and flow rate of carrier gas and was enhanced with decreasing flow rate of argon and increasing preparation temperature. The SEM observation suggested that the obtained samples had a fine microsphere consisted of further smaller primary grains. The microsphere size of sample was about 1 µm, and size distribution was between 0.5 and 5 µm.