Online ISSN : 1347-5320
Print ISSN : 1345-9678
ISSN-L : 1345-9678
Microstructure, Corrosion Behaviors in Different Simulated Body Fluids and Cytotoxicity of Zn–Li Alloy as Biodegradable Material
Yu ZhangYujiao LuXuemei XuLiangjian ChenTao XiaoXier LuoYang YanDing LiYilong DaiKun Yu
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2019 Volume 60 Issue 4 Pages 583-586


Zn-based biodegradable materials have aroused wide attention due to promising biodegradability and adaptability to tissue regeneration in recent years. Zn–0.5%Li alloys was cast and hot extruded in this study. The microstructure, electrochemical properties and cytocompatibility of the as-extruded Zn–0.5%Li alloy were investigated. Four different simulated body fluids (Ringer’s solution, simulated body fluid (SBF), Dulbecco’s Modified Eagle Medium (DMEM) and DMEM-supplementing with 10% fetal bovine serum (DMEMp)) were employed to study the corrosion behavior of the alloy. The result indicated that Zn–0.5%Li alloy was composed of the matrix Zn and the second phase LiZn4. It showed a higher corrosion resistance in the buffer solutions than that in Ringer’s solution, the corrosion rate can be ranked as Ringer’s > DMEMp > DMEM > SBF. What’s more, the cytotoxicity test shows that the alloy is not toxic to BMSCs. Zn–0.5%Li alloy has the potential to be the biodegradable metal.

Fig. 1 (a) X-ray diffraction pattern, (b) optical micrograph in the extrusion direction and (c, d) TEM bright-field micrographs of as-extruded Zn–0.5%Li alloy. Fullsize Image
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© 2019 The Japan Institute of Metals and Materials
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