Titanium (Ti)-based materials are gaining a lot of attentions in fields including aerospace, medical devices, welfare goods, antibacterial materials, consumer goods, chemical plants, electric generation, ocean thermal energy conversion, and armors. Using an additive manufacturing (AM) to make complex shaped products of Ti-based materials is a topic of research globally. For AM of Ti-based materials, not only processing, but also fundamental research on topics such as solidification, heat flow, crystal graphic analysis, and alloy design are becoming more popular. National projects including Ti-based materials managed by ISMA (Innovative Structural Materials Association), SIP (Cross-materials Strategic Innovation Program) and TRAHAM (Technology Research Association for Future Additive Manufacturing Unions), are also in progress. The 14th World Conference on Titanium, which is the largest international conference on Ti-based materials, was held from June 10–14, 2019 at Nantes in France. Therefore, it is now a good time to publish a special issue on the latest topics related to Ti-based materials. Approximately 20 fruitful original technical papers related to all the fields of Ti-based materials including air craft structures and biomedical implants, their surface modifications to enhance the biocompatibility, AM processing, low cost manufacturing, deformation behaviors, and mechanical properties, and effects of low cost elements on their properties are included in this special issue. We are grateful to all the authors for their contributions. We hope this special issue helps to solve important questions related to Ti-based materials.