The liposome modified with simple ligand and metal ions shows the superoxide dismutase-like activity. The mem-brane fluidity of various liposomes modified with the functional ligand (Dodecanoyl-His; Dodec-His) and the cluster-ing of the ligand on the liposome surface were first characterized, showing that the clustering of Dodec-His could beinduced on the liposome surface at gel-phase. The capacity of adsorption of Cu and Zn was found to be increaseddependently on the type of liposome, resulting in the maximal adsorption in liposome prepared by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) at gel state and with higher ligand clustering state. As a result on the SOD-likeactivity of the metal/ligand-modified liposome, the SOD-like activity was found to be induced by using the above lipo-somes although its activity level is not so high.
